Structure of PDB 3tq6 Chain A

Receptor sequence

>3tq6A (length=194) Species: 9606 (Homo sapiens) [Search protein sequence]

SVLASCPKKPVSSYLRFSKEQLPIFKAQNPDAKTTELIRRIAQRWRELPD
SKKKIYQDAYRAEWQVYKEEISRFKEQLTPSQIMSLEKEIMDKHLKRKAM
TKKKELTLLGKPKRPRSAYNVYVAERFQEAKGDSPQEKLKTVKENWKNLS
DSEKELYIQHAKEDETRYHNEMKSWEEQMIEVGRKDLLRRTIKK

3D structure

PDB

3tq6 Human mitochondrial transcription factor A induces a U-turn structure in the light strand promoter.

Chain

Resolution

2.45 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	dna	A	V54 L58 K62 L65 K69 T77 I81 K146 T150 R157 Y162 Q179 L182 K186 W189 Y211 R232 R233 T234 K236	V11 L15 K19 L22 K26 T34 I38 K103 T107 R114 Y119 Q136 L139 K143 W146 Y168 R189 R190 T191 K193
BS02	dna	A	Y57 T78 I81 R82 A85 W88 R89 Y103 K139 R140 M143 T144 K147 K156 R157 N163 V166 A167 F170 P178	Y14 T35 I38 R39 A42 W45 R46 Y60 K96 R97 M100 T101 K104 K113 R114 N120 V123 A124 F127 P135
BS03	dna	A	K52 W107	K9 W64

External links

PDB	RCSB:3tq6, PDBe:3tq6, PDBj:3tq6
PDBsum	3tq6
PubMed	22037172
UniProt	Q00059\|TFAM_HUMAN Transcription factor A, mitochondrial (Gene Name=TFAM)

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