Structure of PDB 3tpx Chain A

Receptor sequence
>3tpxA (length=84) Species: 9606 (Homo sapiens) [Search protein sequence]
TLVRPKPLLLKLLKSVGAQKDTYTMKEVLFYLGQYIMTKRLYDEKQQHIV
YCSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLVV
3D structure
PDB3tpx An Ultrahigh Affinity d-Peptide Antagonist Of MDM2.
ChainA
Resolution1.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.2.27: RING-type E3 ubiquitin transferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A K51 L54 F55 G58 I61 Y67 Q72 H73 V93 K94 H96 I99 Y100 K26 L29 F30 G33 I36 Y42 Q47 H48 V68 K69 H71 I74 Y75
BS02 peptide A H96 R97 H71 R72
Gene Ontology
Biological Process
GO:0043066 negative regulation of apoptotic process
GO:0051726 regulation of cell cycle
Cellular Component
GO:0005634 nucleus

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Biological Process
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Cellular Component
External links
PDB RCSB:3tpx, PDBe:3tpx, PDBj:3tpx
PDBsum3tpx
PubMed22694121
UniProtQ00987|MDM2_HUMAN E3 ubiquitin-protein ligase Mdm2 (Gene Name=MDM2)

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