Structure of PDB 3tpm Chain A

Receptor sequence
>3tpmA (length=422) Species: 10090 (Mus musculus) [Search protein sequence]
NWSVEDIVKGINSNNLESQLQATQAARKLLSREKQPPIDNIIRAGLIPKF
VSFLGKTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASP
HAHISEQAVWALGNIAGDGSAFRDLVIKHGAIDPLLALLAVPDLSTLACG
YLRNLTWTLSNLCRNKNPAPPLDAVEQILPTLVRLLHHNDPEVLADSCWA
ISYLTDGPNERIEMVVKKGVVPQLVKLLGATELPIVTPALRAIGNIVTGT
DEQTQKVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVV
NHGLVPFLVGVLSKADFKTQKEAAWAITNYTSGGTVEQIVYLVHCGIIEP
LMNLLSAKDTKIIQVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIE
ALQRHENESVYKASLNLIEKYF
3D structure
PDB3tpm Sensing actin dynamics: structural basis for G-actin-sensitive nuclear import of MAL
ChainA
Resolution2.1 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A S105 F138 W142 N146 S149 G150 T155 Q181 W184 N188 G191 D192 N228 W231 R238 D270 W273 V321 T322 T328 W357 N361 E396 W399 S31 F64 W68 N72 S75 G76 T81 Q107 W110 N114 G117 D118 N154 W157 R164 D196 W199 V247 T248 T254 W283 N287 E322 W325
External links
PDB RCSB:3tpm, PDBe:3tpm, PDBj:3tpm
PDBsum3tpm
PubMed21964294
UniProtP52293|IMA1_MOUSE Importin subunit alpha-1 (Gene Name=Kpna2)

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