Structure of PDB 3to6 Chain A

Receptor sequence
>3to6A (length=276) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence]
EVARVRNLNRIIMGKYEIEPWYFSPYPIELTDEDFIYIDDFTLQYFGSKK
QYERYRKKCTLRHPPGNEIYRDDYVSFFEIDGRKQRTWCRNLCLLSKLFL
DHKTLYYDVDPFLFYCMTRRDELGHHLVGYFSKEKESADGYNVACILTLP
QYQRMGYGKLLIEFSYELSKKENKVGSPEKPLSDLGLLSYRAYWSDTLIT
LLVEHQKEITIDEISSMTSMTTTDILHTAKTLNILRYYKGQHIIFLNEDI
LDRYNRLKAKKRRTIDPNRLIWKPPV
3D structure
PDB3to6 MYST protein acetyltransferase activity requires active site lysine autoacetylation.
ChainA
Resolution2.1 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) C304 E338
Catalytic site (residue number reindexed from 1) C145 E179
Enzyme Commision number 2.3.1.-
2.3.1.48: histone acetyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A L259 K262 T263 A303 C304 L100 K103 T104 A144 C145
BS02 CMC A F258 L259 A303 I305 L306 T307 Q312 R313 M314 G315 G317 L341 S342 R421 F99 L100 A144 I146 L147 T148 Q153 R154 M155 G156 G158 L182 S183 R262
Gene Ontology
Molecular Function
GO:0004402 histone acetyltransferase activity
Biological Process
GO:0006355 regulation of DNA-templated transcription

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Molecular Function
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Biological Process
External links
PDB RCSB:3to6, PDBe:3to6, PDBj:3to6
PDBsum3to6
PubMed22020126
UniProtQ08649|ESA1_YEAST Histone acetyltransferase ESA1 (Gene Name=ESA1)

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