Structure of PDB 3tnl Chain A

Receptor sequence
>3tnlA (length=288) Species: 169963 (Listeria monocytogenes EGD-e) [Search protein sequence]
KITERITGHTELIGLIATPIRHSLSPTMHNEAFAKLGLDYVYLAFEVGDK
ELKDVVQGFRAMNLRGWNVSMPNKTNIHKYLDKLSPAAELVGAVNTVVND
DGVLTGHITDGTGYMRALKEAGHDIIGKKMTICGAGGAATAICIQAALDG
VKEISIFNRKDDFYANAEKTVEKINSKTDCKAQLFDIEDHEQLRKEIAES
VIFTNATGVGMKPFEGETLLPSADMLRPELIVSDVVYKPTKTRLLEIAEE
QGCQTLNGLGMMLWQGAKAFEIWTHKEMPVDYIKEILF
3D structure
PDB3tnl 1.45 Angstrom Crystal Structure of Shikimate 5-dehydrogenase from Listeria monocytogenes in Complex with Shikimate and NAD.
ChainA
Resolution1.45 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.1.1.25: shikimate dehydrogenase (NADP(+)).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NAD A M74 G137 A138 G139 G140 A141 N161 R162 D164 F166 T210 V212 M214 F217 V238 Y240 M264 M265 M71 G134 A135 G136 G137 A138 N158 R159 D161 F163 T207 V209 M211 F214 V235 Y237 M261 M262
BS02 SKM A S26 S28 N71 S73 K77 N98 D113 Q268 S23 S25 N68 S70 K74 N95 D110 Q265
Gene Ontology
Molecular Function
GO:0004764 shikimate 3-dehydrogenase (NADP+) activity
GO:0016491 oxidoreductase activity
GO:0050661 NADP binding
Biological Process
GO:0008652 amino acid biosynthetic process
GO:0009073 aromatic amino acid family biosynthetic process
GO:0009423 chorismate biosynthetic process
GO:0019632 shikimate metabolic process

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Molecular Function
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Biological Process
External links
PDB RCSB:3tnl, PDBe:3tnl, PDBj:3tnl
PDBsum3tnl
PubMed
UniProtQ8Y9N5|AROE_LISMO Shikimate dehydrogenase (NADP(+)) (Gene Name=aroE)

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