Structure of PDB 3tnh Chain A

Receptor sequence
>3tnhA (length=289) Species: 9606 (Homo sapiens) [Search protein sequence]
VECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKE
GFPITALREIKILQLLKHENVVNLIEICRTSIYLVFDFCEHDLAGLLSNV
LVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLAD
FGLARAFSNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWT
RSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNKVKDRLKAYVRDPYAL
DLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGML
3D structure
PDB3tnh The CDK9 C-helix Exhibits Conformational Plasticity That May Explain the Selectivity of CAN508.
ChainA
Resolution3.202 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D149 K151 A153 N154 D167 T191
Catalytic site (residue number reindexed from 1) D132 K134 A136 N137 D150 T167
Enzyme Commision number 2.7.11.22: cyclin-dependent kinase.
2.7.11.23: [RNA-polymerase]-subunit kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 F18 A A46 E66 F103 C106 L156 D167 A39 E59 F86 C89 L139 D150 PDBbind-CN: -logKd/Ki=6.46,IC50=0.35uM
BindingDB: IC50=3.5e+2nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:3tnh, PDBe:3tnh, PDBj:3tnh
PDBsum3tnh
PubMed22292676
UniProtP50750|CDK9_HUMAN Cyclin-dependent kinase 9 (Gene Name=CDK9)

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