Structure of PDB 3tl0 Chain A

Receptor sequence
>3tl0A (length=99) Species: 9606 (Homo sapiens) [Search protein sequence]
RWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHI
KIQNTGDYYDLYGGEKFATLAELVQYYMEHHGQLKEKNGDVIELKYPLN
3D structure
PDB3tl0 Simultaneous binding of two peptidyl ligands by a SRC homology 2 domain.
ChainA
Resolution2.05 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.3.48: protein-tyrosine-phosphatase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A G13 E17 R32 S34 K35 S36 T52 H53 K55 K89 E90 K91 G9 E13 R28 S30 K31 S32 T48 H49 K51 K85 E86 K87
External links
PDB RCSB:3tl0, PDBe:3tl0, PDBj:3tl0
PDBsum3tl0
PubMed21800896
UniProtQ06124|PTN11_HUMAN Tyrosine-protein phosphatase non-receptor type 11 (Gene Name=PTPN11)

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