Structure of PDB 3tkz Chain A

Receptor sequence
>3tkzA (length=100) Species: 9606 (Homo sapiens) [Search protein sequence]
RRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTH
IKIQNTGDYYDLYGGEKFATLAELVQYYMEHHGQLKEKNGDVIELKYPLN
3D structure
PDB3tkz Simultaneous binding of two peptidyl ligands by a SRC homology 2 domain.
ChainA
Resolution1.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.3.48: protein-tyrosine-phosphatase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A R32 S34 K35 S36 T42 H53 K55 E90 R29 S31 K32 S33 T39 H50 K52 E87
BS02 peptide A G67 Q87 L88 K89 E90 K91 G64 Q84 L85 K86 E87 K88
External links
PDB RCSB:3tkz, PDBe:3tkz, PDBj:3tkz
PDBsum3tkz
PubMed21800896
UniProtQ06124|PTN11_HUMAN Tyrosine-protein phosphatase non-receptor type 11 (Gene Name=PTPN11)

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