Structure of PDB 3tkd Chain A

Receptor sequence
>3tkdA (length=262) Species: 10116 (Rattus norvegicus) [Search protein sequence]
GANKTVVVTTILESPYVMMKKNHEMLEGNERYEGYCVDLAAEIAKHCGFK
YKLTIVGDGKYGARDADTKIWNGMVGELVYGKADIAIAPLTITYVREEVI
DFSKPFMSLGISIMIKKGTPIESAEDLSKQTEIAYGTLDSGSTKEFFRRS
KIAVFDKMWTYMRSAEPSVFVRTTAEGVARVRKSKGKYAYLLESTMNEYI
EQRKPCDTMKVGGNLDSKGYGIATPKGSSLGNAVNLAVLKLSEQGLLDKL
KNKWWYDKGECG
3D structure
PDB3tkd Thermodynamics and structural analysis of positive allosteric modulation of the ionotropic glutamate receptor GluA2.
ChainA
Resolution1.45 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GLU A Y61 L90 T91 R96 G141 S142 T143 E193 Y61 L90 T91 R96 G141 S142 T143 E193
BS02 CYZ A P105 M107 S108 L239 S242 L247 D248 P105 M107 S108 L239 S242 L247 D248 BindingDB: EC50=7600nM
BS03 CYZ A I92 S217 K218 G219 I92 S217 K218 G219 BindingDB: EC50=7600nM
Gene Ontology
Molecular Function
GO:0015276 ligand-gated monoatomic ion channel activity
Cellular Component
GO:0016020 membrane

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Molecular Function
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Cellular Component
External links
PDB RCSB:3tkd, PDBe:3tkd, PDBj:3tkd
PDBsum3tkd
PubMed21895609
UniProtP19491|GRIA2_RAT Glutamate receptor 2 (Gene Name=Gria2)

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