Structure of PDB 3tkc Chain A

Receptor sequence
>3tkcA (length=254) Species: 9606 (Homo sapiens) [Search protein sequence]
SLRPKLSEEQQRIIAILLDAHHKTYDPTYSDFCQFRPPVRVNDGGGSVTL
ELSQLSMLPHLADLVSYSIQKVIGFAKMIPGFRDLTSEDQIVLLKSSAIE
VIMLRSNESFTMDDMSWTCGNQDYKYRVSDVTKAGHSLELIEPLIKFQVG
LKKLNLHEEEHVLLMAICIVSPDRPGVQDAALIEAIQDRLSNTLQTYIRC
RHPPPGSHLLYAKMIQKLADLRSLNEEHSKQYRCLSFQPECSMKLTPLVL
EVFG
3D structure
PDB3tkc Design, synthesis, evaluation, and structure of vitamin D analogues with furan side chains.
ChainA
Resolution1.75 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FMV A Y143 V234 S237 I268 R274 S275 S278 W286 V300 H305 H397 Y25 V65 S68 I99 R105 S106 S109 W117 V131 H136 H228
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription

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Molecular Function
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Biological Process
External links
PDB RCSB:3tkc, PDBe:3tkc, PDBj:3tkc
PDBsum3tkc
PubMed22162241
UniProtP11473|VDR_HUMAN Vitamin D3 receptor (Gene Name=VDR)

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