Structure of PDB 3tj2 Chain A

Receptor sequence
>3tj2A (length=90) Species: 9606 (Homo sapiens) [Search protein sequence]
ASEQETLVRPKPLLLKLLKSVGAQKDTYTMKEVLFYLGQYIMTKRLYDEK
QQHIVYCSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLVVV
3D structure
PDB3tj2 Ugi Multicomponent Reaction Derived p53-Mdm2 Antagonists
ChainA
Resolution2.1 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.2.27: RING-type E3 ubiquitin transferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 TJ2 A L54 G58 I61 Y67 F86 F91 V93 H96 I99 Y100 L34 G38 I41 Y47 F66 F71 V73 H76 I79 Y80 BindingDB: Ki=400nM
Gene Ontology
Biological Process
GO:0043066 negative regulation of apoptotic process
GO:0051726 regulation of cell cycle
Cellular Component
GO:0005634 nucleus

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Biological Process
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Cellular Component
External links
PDB RCSB:3tj2, PDBe:3tj2, PDBj:3tj2
PDBsum3tj2
PubMed
UniProtQ00987|MDM2_HUMAN E3 ubiquitin-protein ligase Mdm2 (Gene Name=MDM2)

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