Structure of PDB 3thp Chain A

Receptor sequence
>3thpA (length=304) Species: 9606 (Homo sapiens) [Search protein sequence]
TLLRHEGIETVSYATQSLVVANGGLGNGVSRNQLLPVLEKCGLVDALLMP
PNKPYSFARYRTTEESKRAYVTLNGKEVVDDLGQKITLYLNFVEKVQWKE
LRPQALPPGLMVVEEIISSEEEKMLLESVRRVKHFGYKDKPLSGGLPDIC
ESFLEKWLRKGYIKHKPDQMTINQYEPGQGIPAHIDTHSAFEDEIVSLSL
GSEIVMDFKHPDGIAVPVMLPRRSLLVMTGESRYLWTHGITCRKFDTVQA
SEKSGIITSDVGDLTLSKRGLRTSFTFRKVRQTPCNCSYPLVCDSQRKEN
LYFQ
3D structure
PDB3thp Crystal structure and RNA binding properties of the RNA recognition motif (RRM) and AlkB domains in human AlkB homolog 8 (ABH8), an enzyme catalyzing tRNA hypermodification.
ChainA
Resolution3.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.229: tRNA (carboxymethyluridine(34)-5-O)-methyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A H242 C341 C349 H188 C285 C293
BS02 MN A H238 D240 H292 H184 D186 H238
BS03 AKG A H238 S251 M260 R328 S330 T332 H184 S197 M206 R272 S274 T276
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003723 RNA binding
Biological Process
GO:0070988 demethylation

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Molecular Function
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Biological Process
External links
PDB RCSB:3thp, PDBe:3thp, PDBj:3thp
PDBsum3thp
PubMed22065580
UniProtQ96BT7|ALKB8_HUMAN Alkylated DNA repair protein alkB homolog 8 (Gene Name=ALKBH8)

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