Structure of PDB 3thb Chain A

Receptor sequence
>3thbA (length=287) Species: 9606 (Homo sapiens) [Search protein sequence]
EVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLK
PHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLEL
HKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVK
IGDFGLATKVEYDGERKKVLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIM
YTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPT
ARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIA
3D structure
PDB3thb Discovery of a Potent and Orally Bioavailable Benzolactam-Derived Inhibitor of Polo-Like Kinase 1 (MLN0905).
ChainA
Resolution2.5 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D176 K178 G180 N181 D194 T214
Catalytic site (residue number reindexed from 1) D135 K137 G139 N140 D153 T173
Enzyme Commision number 2.7.11.21: polo kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A H93 C212 H52 C171
BS02 3TA A L59 G60 K61 C67 A80 L132 C133 R136 E140 F183 D194 L18 G19 K20 C26 A39 L91 C92 R95 E99 F142 D153 MOAD: ic50=2nM
PDBbind-CN: -logKd/Ki=8.70,IC50=2nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:3thb, PDBe:3thb, PDBj:3thb
PDBsum3thb
PubMed22070629
UniProtP53350|PLK1_HUMAN Serine/threonine-protein kinase PLK1 (Gene Name=PLK1)

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