Structure of PDB 3tgs Chain A

Receptor sequence
>3tgsA (length=345) Species: 11676 (Human immunodeficiency virus 1) [Search protein sequence]
VWKEAKTTLFCASDAKAYEKEVHNVWATHACVPTDPNPQEMVLANVTENF
NMWKNDMVEQMHEDIISLWDESLKPCVKLTGGSAITQACPKVSFDPIPLH
YCAPAGFAILKCNNKTFNGTGPCRNVSTVQCTHGIKPVVSTQLLLNGSLA
EEEIIIRSENLTNNAKTIIVHLNESVNIVCTRPNNIRQAHCNINESKWNN
TLQKVGEELAKHFPSKTIKFEPSSGGDLEITTHSFNCRGEFFYCNTSDLF
NGTYRNGTYNHTGRSSNGTITLQCKIKQIINMWQEVGRAIYAPPIEGEIT
CNSNITGLLLLRDGGNDTETFRPGGGDMRDNWRSELYKYKVVEIK
3D structure
PDB3tgs Unliganded HIV-1 gp120 core structures assume the CD4-bound conformation with regulation by quaternary interactions and variable loops.
ChainA
Resolution2.7 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 03G A V255 E370 F376 N377 F382 I424 N425 M426 W427 E429 V430 G473 M475 V139 E229 F235 N236 F241 I280 N281 M282 W283 E285 V286 G326 M328 PDBbind-CN: -logKd/Ki=5.39,Kd=4.1uM
Gene Ontology

View graph for
Cellular Component
External links
PDB RCSB:3tgs, PDBe:3tgs, PDBj:3tgs
PDBsum3tgs
PubMed22451932
UniProtC6G099

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