Structure of PDB 3tba Chain A

Receptor sequence
>3tbaA (length=660) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence]
AARIAISNLHKQTTKQFSKVVEDLYRYVNAATGKPAPMISDDVYNIVMEN
KDKLNSAIVYDRDFQYSYFGFKTLERSYLLRINGQVAERPQHLIMRVALG
IHGRDIEAALETYNLMSLKYFTHASPTLFNAGTPKPQMSSCFLVAMKEDS
IEGIYDTLKECALISKTAGGIGLHIHNIRSTGSYIAGTNGTSNGLIPMIR
VFNNTARYVDAGGNKRPGAFALYLEPWHADIFDFIDIRKNHGKEEIRARD
LFPALWIPDLFMKRVEENGTWTLFSPTSAPGLSDCYGDEFEALYTRYEKE
GRGKTIKAQKLWYSILEAQTETGTPFVVYKDACNRKSNQKNLGVIKSSNL
CCEIVEYSAPDETAVCNLASVALPAFIETSEDGKTSTYNFKKLHEIAKVV
TRNLNRVIDRNYYPVEEARKSNMRHRPIALGVQGLADTFMLLRLPFDSEE
ARLLNIQIFETIYHASMEASCELAQKDGPYETFQGSPASQGILQFDMWDQ
KPYGMWDWDTLRKDIMKHGVRNSLTMAPMPTASTSQILGYNECFEPVTSN
MYQVVNPYLLRDLVDLGIWDEGMKQYLITQNGSIQGLPNVPQELKDLYKT
VWEISQKTIINMAADRSVYIDQSHSLNLFLRAPTMGKLTSMHFYGWKKGL
KTGMYYLRTQ
3D structure
PDB3tba Role of Arginine 293 and Glutamine 288 in Communication between Catalytic and Allosteric Sites in Yeast Ribonucleotide Reductase.
ChainA
Resolution2.8 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) C218 N426 C428 E430 C443 Y741 Y742
Catalytic site (residue number reindexed from 1) C141 N349 C351 E353 C366 Y655 Y656
Enzyme Commision number 1.17.4.1: ribonucleoside-diphosphate reductase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 DGT A D226 S227 R256 I262 A263 G264 D149 S150 R179 I185 A186 G187
BS02 ADP A A201 S202 S217 G247 R293 L427 C428 E430 P607 T608 S610 T611 A124 S125 S140 G170 R216 L350 C351 E353 P530 T531 S533 T534
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0004748 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016491 oxidoreductase activity
GO:0042802 identical protein binding
Biological Process
GO:0009263 deoxyribonucleotide biosynthetic process
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005971 ribonucleoside-diphosphate reductase complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3tba, PDBe:3tba, PDBj:3tba
PDBsum3tba
PubMed22465672
UniProtP21524|RIR1_YEAST Ribonucleoside-diphosphate reductase large chain 1 (Gene Name=RNR1)

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