Structure of PDB 3tb9 Chain A

Receptor sequence
>3tb9A (length=643) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence]
QTTKQFSKVVEDLYRYVNAATGKPAPMISDDVYNIVMENKDKLNSAIVYD
RDFQYSYFGFKTLERSYLLRINGQVAERPQHLIMRVALGIHGRDIEAALE
TYNLMSLKYFTHASPTLFNAGTPKPQMSSCFLVAMKEDSIEGIYDTLKEC
ALISKTAGGIGLHIHNIRSTGSYIAGTNGTSNGLIPMIRVFNNTARYVDG
AFALYLEPWHADIFDFIDIRKNHGKEEIRARDLFPALWIPDLFMKRVEEN
GTWTLFSPTSAPGLSDCYGDEFEALYTRYEKEGRGKTIKAQKLWYSILEA
QTETGTPFVVYKDACNRKSNQKNLGVIKSSNLCCEIVEYSAPDETAVCNL
ASVALPAFIETSEDGKTSTYNFKKLHEIAKVVTRNLNRVIDRNYYPVEEA
RKSNMRHRPIALGVQGLADTFMLLRLPFDSEEARLLNIQIFETIYHASME
ASCELAQKDGPYETFQGSPASQGILQFDMWDQKPYGMWDWDTLRKDIMKH
GVRNSLTMAPMPTASTSQILGYNECFEPVTSNMYFQVVNPYLLRDLVDLG
IWDEGMKQYLITQNGSIQGLPNVPQELKDLYKTVWEISQKTIINMAADRS
VYIDQSHSLNLFLRAPTMGKLTSMHFYGWKKGLKTGMYYLRTQ
3D structure
PDB3tb9 Role of Arginine 293 and Glutamine 288 in Communication between Catalytic and Allosteric Sites in Yeast Ribonucleotide Reductase.
ChainA
Resolution2.53 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) C218 N426 C428 E430 C443 Y741 Y742
Catalytic site (residue number reindexed from 1) C130 N331 C333 E335 C348 Y638 Y639
Enzyme Commision number 1.17.4.1: ribonucleoside-diphosphate reductase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CDP A A201 S202 S217 C218 G246 G247 L427 C428 E430 L445 M606 T608 A609 T611 A113 S114 S129 C130 G158 G159 L332 C333 E335 L350 M511 T513 A514 T516
BS02 ANP A D226 S227 I228 R256 I262 A263 D138 S139 I140 R168 I174 A175
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0004748 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016491 oxidoreductase activity
GO:0042802 identical protein binding
Biological Process
GO:0009263 deoxyribonucleotide biosynthetic process
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005971 ribonucleoside-diphosphate reductase complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3tb9, PDBe:3tb9, PDBj:3tb9
PDBsum3tb9
PubMed22465672
UniProtP21524|RIR1_YEAST Ribonucleoside-diphosphate reductase large chain 1 (Gene Name=RNR1)

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