Structure of PDB 3t9f Chain A

Receptor sequence

>3t9fA (length=318) Species: 9606 (Homo sapiens)

QIVVGICSMAKKSKSKPMKEILERISLFKYITVVVFEEEVILNEPVENWP
LCDCLISFHSKGFPLDKAVAYAKLRNPFVINDLNMQYLIQDRREVYSILQ
AEGILLPRYAILNRDPNNPKECNLIEGEDHVEVNGEVFQKPFVEKPVSAE
DHNVYIYYPTSAGGGSQRLFRKIGSRSSVYSPESNVRKTGSYIYEEFMPT
DGTDVKVYTVGPDYAHAEARKSPALDGKVERDSEGKEVRYPVILNAREKL
IAWKVCLAFKQTVCGFDLLRANGQSYVCDVNGFSFVKNSMKYYDDCAKIL
GNIVMRELAPQFHIPWSI

3D structure

• PDB: 3t9f Structural basis for an inositol pyrophosphate kinase surmounting phosphate crowding.
• Chain: A
• Resolution: 2.0 Å

Enzymatic activity

• Enzyme Commision number: 2.7.4.24: diphosphoinositol-pentakisphosphate 1-kinase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	ADP	A	R134 V185 K187 H194 L211 E237 F239 M240 D246 L311 D321	R92 V143 K145 H152 L169 E195 F197 M198 D204 L269 D279
BS02	I8P	A	K53 K54 R213 K214 K248 R273 R281 D321 N323 K329	K11 K12 R171 K172 K206 R231 R239 D279 N281 K287
BS03	MG	A	D309 D321	D267 D279
BS04	MG	A	S68 F70 I73	S26 F28 I31
BS05	MG	A	T251 C298 Q303 T304 V305 C306	T209 C256 Q261 T262 V263 C264

Gene Ontology

Molecular Function

• GO:0000829 diphosphoinositol pentakisphosphate kinase activity

External links

• PDB: RCSB:3t9f, PDBe:3t9f, PDBj:3t9f
• PDBsum: 3t9f
• PubMed: 22119861
• UniProt: O43314|VIP2_HUMAN Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 (Gene Name=PPIP5K2)