Structure of PDB 3t8w Chain A

Receptor sequence
>3t8wA (length=519) Species: 36329 (Plasmodium falciparum 3D7) [Search protein sequence]
ASEVPQVVSLDPTSIPIEYNTPIHDIKVQVYDIKGGCNVEEGLTIFLVNN
PGKENGPVKISSKVNDKQVSEFLKDENMEKFNVKLGTSKHFYMFNDNKNS
VAVGYVGCGSVADLSEADMKRVVLSLVTMLHDNKLSKLTVVFEINVDKNL
FRFFLETLFYEYMTDERFKSTDKNVNMEYIKHLGVYINNADTYKEEVEKA
RVYYFGTYYASQLIAAPSNYCNPVSLSNAAVELAQKLNLEYKILGVKELE
ELKMGAYLSVGKGSMYPNKFIHLTYKSKGDVKKKIALVGKGITFDSGGYN
LKAAPGSMIDLMKFDMSGCAAVLGCAYCVGTLKPENVEIHFLSAVCENMV
SKNSYRPGDIITASNGKTIEVGNTDAEGRLTLADALVYAEKLGVDYIVDI
ATLTGAMLYSLGTSYAGVFGNNEELINKILQSSKTSNEPVWWLPIINEYR
ATLNSKYADINQISSSVKASSIVASLFLKEFVQNTAWAHIDIAGVSWNFK
ARKPKGFGVRLLTEFVLND
3D structure
PDB3t8w Bestatin-based chemical biology strategy reveals distinct roles for malaria M1- and M17-family aminopeptidases
ChainA
Resolution2.0 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) K386 R463
Catalytic site (residue number reindexed from 1) K302 R379
Enzyme Commision number 3.4.11.1: leucyl aminopeptidase.
3.4.13.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CO3 A A460 G462 R463 L487 A376 G378 R379 L403
BS02 ZN A D379 D459 E461 D295 D375 E377
BS03 ZN A K374 D379 D399 E461 K290 D295 D315 E377
BS04 DGZ A K374 D379 A388 G390 M392 M396 F398 D399 N457 D459 E461 T486 L487 T488 G489 A490 Y493 I547 K290 D295 A304 G306 M308 M312 F314 D315 N373 D375 E377 T402 L403 T404 G405 A406 Y409 I463 MOAD: Ki=330nM
PDBbind-CN: -logKd/Ki=7.54,Ki=29nM
Gene Ontology
Molecular Function
GO:0030145 manganese ion binding
GO:0046872 metal ion binding
GO:0070006 metalloaminopeptidase activity
Biological Process
GO:0006508 proteolysis
GO:0019538 protein metabolic process
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3t8w, PDBe:3t8w, PDBj:3t8w
PDBsum3t8w
PubMed21844374
UniProtQ8IL11|AMPL_PLAF7 Leucine aminopeptidase (Gene Name=LAP)

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