Structure of PDB 3t8o Chain A

Receptor sequence
>3t8oA (length=493) Species: 9913 (Bos taurus) [Search protein sequence]
SRDRKYLARLKLPPLSKCEALRESLDLGFEGMCLEQPIGKRLFQQFLRTH
EQHGPALQLWKDIEDYDTADDALRPQKAQALRAAYLEPQAQLFCSFLDAE
TVARARAGAGDGLFQPLLRAVLAHLGQAPFQEFLDSKYFLRFLQWKWLEA
QPMGEDWFLDFRVLGRGGFGEVFACQMKATGKLYACKKLNKKRLKKRKGY
QGAMVEKKILAKVHSRFIVSLAYAFETKTDLCLVMTIMNGGDIRYHIYNV
DEDNPGFQEPRAIFYTAQIVSGLEHLHQRNIIYRDLKPENVLLDDDGNVR
ISDLGLAVELKAGQTKTKGYAGTPGFMAPELLLGEEYDFSVDYFALGVTL
YEMIAARGPFRARGEKVENKELKQRVLEQAVTYPDKFSPASKDFCEALLQ
KDPEKRLGFRDGSCDGLRTHPLFRDISWRQLEAGMLTPPFVPDSRTIQDV
GAFVAFEKADTEFFQEFASGTCPIPWQEEMIETGVFGDLNVWR
3D structure
PDB3t8o Structure of a monomeric variant of rhodopsin kinase at 2.5 A resolution.
ChainA
Resolution2.5 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D314 K316 E318 N319 D332 A341 T352
Catalytic site (residue number reindexed from 1) D285 K287 E289 N290 D303 A312 T323
Enzyme Commision number 2.7.11.14: rhodopsin kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ATP A G196 K216 M267 L321 D332 G167 K187 M238 L292 D303
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004703 G protein-coupled receptor kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0050254 rhodopsin kinase activity
Biological Process
GO:0006468 protein phosphorylation
GO:0007165 signal transduction
GO:0007601 visual perception
GO:0009966 regulation of signal transduction
GO:0016310 phosphorylation
GO:0022400 regulation of opsin-mediated signaling pathway
GO:0046777 protein autophosphorylation
Cellular Component
GO:0001750 photoreceptor outer segment
GO:0005737 cytoplasm
GO:0016020 membrane
GO:0042995 cell projection
GO:0097381 photoreceptor disc membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3t8o, PDBe:3t8o, PDBj:3t8o
PDBsum3t8o
PubMed22684056
UniProtP28327|GRK1_BOVIN Rhodopsin kinase GRK1 (Gene Name=GRK1)

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