Structure of PDB 3t7a Chain A

Receptor sequence
>3t7aA (length=319) Species: 9606 (Homo sapiens) [Search protein sequence]
RQIVVGICSMAKKSKSKPMKEILERISLFKYITVVVFEEEVILNEPVENW
PLCDCLISFHSKGFPLDKAVAYAKLRNPFVINDLNMQYLIQDRREVYSIL
QAEGILLPRYAILNRDPNNPKECNLIEGEDHVEVNGEVFQKPFVEKPVSA
EDHNVYIYYPTSAGGGSQRLFRKIGSRSSVYSPESNVRKTGSYIYEEFMP
TDGTDVKVYTVGPDYAHAEARKSPALDGKVERDSEGKEVRYPVILNAREK
LIAWKVCLAFKQTVCGFDLLRANGQSYVCDVNGFSFVKNSMKYYDDCAKI
LGNIVMRELAPQFHIPWSI
3D structure
PDB3t7a Structural basis for an inositol pyrophosphate kinase surmounting phosphate crowding.
ChainA
Resolution1.7 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.4.24: diphosphoinositol-pentakisphosphate 1-kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ADP A R134 V185 K187 H194 L211 E237 F239 M240 D246 L311 C320 D321 R93 V144 K146 H153 L170 E196 F198 M199 D205 L270 C279 D280
BS02 MG A D321 N323 D280 N282
BS03 MG A D309 D321 D268 D280
BS04 MG A S68 F70 I73 S27 F29 I32
Gene Ontology
Molecular Function
GO:0000829 diphosphoinositol pentakisphosphate kinase activity

View graph for
Molecular Function
External links
PDB RCSB:3t7a, PDBe:3t7a, PDBj:3t7a
PDBsum3t7a
PubMed22119861
UniProtO43314|VIP2_HUMAN Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 (Gene Name=PPIP5K2)

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