Structure of PDB 3t6j Chain A

Receptor sequence
>3t6jA (length=722) Species: 9606 (Homo sapiens) [Search protein sequence]
ADTQYILPNDIGVSSLDCREAFRLLSPTERLYAYHLSRAAWYGGLAVLLQ
TSPEAPYIYALLSRLFRAQDPDQLRQHALAEGLTEEEYQAFLVYAAGVYS
NMGNYKSFGDTKFVPNLPKEKLERVILGSEAAQQHPEEVRGLWQTCGELM
FSLEPRLRHLGLGKEGITTYFSGNCTMEDAKLAQDFLDSQNLSAYNTRLF
KEVDGEGKPYYEVRLASVLGSEPSLDSEVTSKLKSYEFRGSPFQVTRGDY
APILQKVVEQLEKAKAYAANSHQGQMLAQYIESFTQGSIEAHKRGSRFWI
QDKGPIVESYIGFIESYRDPFGSRGEFEGFVAVVNKAMSAKFERLVASAE
QLLKELPWPPTFEKDKFLTPDFTSLDVLTFAGSGIPAGINIPNYDDLRQT
EGFKNVSLGNVLAVAYREKLTFLEEDDKDLYILWKGPSFDVQVGLHALLG
HGSGKLFVQDEKGAFNFDQETVINPETGEQIQSWYRSGETWDSKFSTIAS
SYEECRAESVGLYLCLHPQVLEIFGFEGADAEDVIYVNWLNMVRAGLLAL
EFYTPEAFNWRQAHMQARFVILRVLLEAGEGLVTITPTTGSDGRPDARVR
LDRSKIRSVGKPALERFLRRLQVLKSTGDVAGGRALYEGYATVTDAPPEC
FLTLRDTVLLRKESRKLIVQPNTRLEGSDVQLLEYEASAAGLIRSFSERF
PEDGPELEEILTQLATADARFW
3D structure
PDB3t6j Entropy-driven binding of opioid peptides induces a large domain motion in human dipeptidyl peptidase III.
ChainA
Resolution2.976 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.14.4: dipeptidyl-peptidase III.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A E316 Y318 I386 P387 A388 G389 I390 N391 N394 Q446 V447 H450 H455 E508 E512 H568 R669 E315 Y317 I385 P386 A387 G388 I389 N390 N393 Q442 V443 H446 H451 E504 E508 H564 R665
Gene Ontology
Molecular Function
GO:0004177 aminopeptidase activity
GO:0005515 protein binding
GO:0008235 metalloexopeptidase activity
GO:0008237 metallopeptidase activity
GO:0008239 dipeptidyl-peptidase activity
GO:0008270 zinc ion binding
GO:0046872 metal ion binding
Biological Process
GO:0006508 proteolysis
GO:0030163 protein catabolic process
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0070062 extracellular exosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3t6j, PDBe:3t6j, PDBj:3t6j
PDBsum3t6j
PubMed22493238
UniProtQ9NY33|DPP3_HUMAN Dipeptidyl peptidase 3 (Gene Name=DPP3)

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