Structure of PDB 3t4p Chain A

Receptor sequence
>3t4pA (length=319) Species: 5661 (Leishmania donovani) [Search protein sequence]
AAPFDKSKNVAQSIDQLIGQTPALYLNKLNNTKAKVVLKMECENPMASVK
DRLGFAIYDKAEKEGKLIPGKSIVVESSSGNTGVSLAHLGAIRGYKVIIT
MPESMSLERRCLLRIFGAEVILTPAALGMKGAVAMAKKIVAANPNAVLAD
QFATKYNALIHEETTGPEIWEQTNHNVDCFIAGVGTGGTLTGVARALKKM
GSHARIVAVEPTESPVLSGGKPGPHKIQGIGPGFVPDVLDRSLIDEVLCV
AGDDAIETALKLTRSDGVFCGFSGGANVYAALKIAERPEMEGKTIVTVIP
SFGERYLSTTLYRSVRDEV
3D structure
PDB3t4p The narrow active-site cleft of O-acetylserine sulfhydrylase from Leishmania donovani allows complex formation with serine acetyltransferases with a range of C-terminal sequences
ChainA
Resolution1.77 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) K51 S274
Catalytic site (residue number reindexed from 1) K50 S273
Enzyme Commision number 2.5.1.47: cysteine synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A S79 S80 G81 T83 M130 Q152 F153 G224 P225 H226 G230 G232 P233 S78 S79 G80 T82 M129 Q151 F152 G223 P224 H225 G229 G231 P232
Gene Ontology
Molecular Function
GO:0004124 cysteine synthase activity
Biological Process
GO:0006535 cysteine biosynthetic process from serine
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3t4p, PDBe:3t4p, PDBj:3t4p
PDBsum3t4p
PubMed22868756
UniProtG1C2I2

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