Structure of PDB 3t2t Chain A

Receptor sequence

>3t2tA (length=134) Species: 9606 (Homo sapiens) [Search protein sequence]

ACGLVASNLNLKPGECLRVRGEVAPDAKSFVLNLGKDSNNLCLHFNPRFN
AHGDANTIVCNSKDGGAWGTEQREAVFPFQPGSVAEVCITFDQANLTVKL
PDGYEFKFPNRLNLEAINYMAADGDFKIKCVAFD

3D structure

PDB

3t2t Taloside inhibitors of galectin-1 and galectin-3

Chain

Resolution

1.9 Å

3D
structure

Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	MQT	A	V31 H44 R48 H52 N61 E71	V31 H44 R48 H52 N61 E71	PDBbind-CN: -logKd/Ki=2.40,Kd>4mM BindingDB: Kd=>4000000nM

Gene Ontology

	Biological Process
GO:0002317	plasma cell differentiation
GO:0006915	apoptotic process
GO:0007165	signal transduction
GO:0031295	T cell costimulation
GO:0042981	regulation of apoptotic process
GO:0043065	positive regulation of apoptotic process
GO:0043123	positive regulation of canonical NF-kappaB signal transduction
GO:0045445	myoblast differentiation
GO:0046598	positive regulation of viral entry into host cell
GO:0050729	positive regulation of inflammatory response
GO:0098609	cell-cell adhesion
GO:2000329	negative regulation of T-helper 17 cell lineage commitment
GO:2001200	positive regulation of dendritic cell differentiation

	Cellular Component
GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0005737	cytoplasm
GO:0005788	endoplasmic reticulum lumen
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0062023	collagen-containing extracellular matrix
GO:0070062	extracellular exosome
GO:1990724	galectin complex

External links

PDB	RCSB:3t2t, PDBe:3t2t, PDBj:3t2t
PDBsum	3t2t
PubMed	22136701
UniProt	P09382\|LEG1_HUMAN Galectin-1 (Gene Name=LGALS1)