Structure of PDB 3t01 Chain A

Receptor sequence
>3t01A (length=413) Species: 266834 (Sinorhizobium meliloti 1021) [Search protein sequence]
MSKISVTVNGRRYPWPRVPAIAVCLDGCEPAYLDAAIDAGLMPALKRIKE
RGAVRLAHSVIPSFTNPNNLSIATGSPPAVHGICGNYLYEPSTGEEVMMN
DPKFLRAPTIFQAFYDAGARVAVVTAKDKLRALLGKGLRFDEGRAVCFSS
EKSDKATRAEHGIDNASAWLGRPVPEVYSAALSEFVFAAGVKLLREFRPD
IMYLTTTDYVQHKYAPGVPEANSFYEMFDRYLAELDGLGAAIVVTADHGM
KPKHKADGSPDVIYVQDLLDEWLGKDAARVILPITDPYVVHHGALGSFAT
AYLPDGCDRSEIMARLKAIQGVDVVLGREEACRRFELPEDRIGDIVLVSS
ENKTLGTSEHRHDLAALDEPLRSHGGLTEQEVPFIVNRVLPELPNAPRLR
NFDAFFYAVTAAA
3D structure
PDB3t01 Structural and mechanistic insights into C-p bond hydrolysis by phosphonoacetate hydrolase.
ChainA
Resolution1.6 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.1.9: nucleotide diphosphatase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A D29 T68 D250 H251 D26 T65 D247 H248
BS02 ZN A D211 H215 H377 D208 H212 H374
BS03 PPF A T68 D211 I287 H377 T65 D208 I284 H374 MOAD: Ki=33uM
PDBbind-CN: -logKd/Ki=4.48,Ki=33uM
Gene Ontology
Molecular Function
GO:0016787 hydrolase activity
GO:0046872 metal ion binding
GO:0047400 phosphonoacetate hydrolase activity
GO:0047429 nucleoside triphosphate diphosphatase activity

View graph for
Molecular Function
External links
PDB RCSB:3t01, PDBe:3t01, PDBj:3t01
PDBsum3t01
PubMed22035792
UniProtQ92UV8

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