Structure of PDB 3szq Chain A

Receptor sequence
>3szqA (length=199) Species: 284812 (Schizosaccharomyces pombe 972h-) [Search protein sequence]
QSFRDNLKVYIESPESYKNVIYYDDDVVLVRDMFPKSKMHLLLMTRDPHL
THVHPLEIMMKHRSLVEKLVSYVQGDLSGLIFDEARNCLSQQLTNEALCN
YIKVGFHAGPSMNNLHLHIMTLDHVSPSLKNSAHYISFTSPFFVKIDTPT
SNLPTRGTLTSLFQEDLKCWRCGETFGRHFTKLKAHLQEEYDDWLDKSV
3D structure
PDB3szq Structure of an aprataxin-DNA complex with insights into AOA1 neurodegenerative disease.
ChainA
Resolution2.353 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.1.71: adenosine-5'-diphospho-5'-[DNA] diphosphatase.
3.6.1.72: DNA-3'-diphospho-5'-guanosine diphosphatase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna A F34 F65 K67 S142 M143 K161 H165 S229 V230 F3 F34 K36 S111 M112 K130 H134 S198 V199 PDBbind-CN: Kd=190nM
BS02 dna A F34 R209 F211 T212 F3 R178 F180 T181 PDBbind-CN: Kd=190nM
BS03 AMP A L38 Y41 D63 M64 F65 H138 P141 S142 M143 H147 H149 L7 Y10 D32 M33 F34 H107 P110 S111 M112 H116 H118
BS04 ZN A C200 C203 H217 E221 C169 C172 H186 E190
Gene Ontology
Molecular Function
GO:0003824 catalytic activity

View graph for
Molecular Function
External links
PDB RCSB:3szq, PDBe:3szq, PDBj:3szq
PDBsum3szq
PubMed21984210
UniProtO74859|APTX_SCHPO Aprataxin-like protein (Gene Name=hnt3)

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