Structure of PDB 3szc Chain A

Receptor sequence

>3szcA (length=421) Species: 243159 (Acidithiobacillus ferrooxidans ATCC 23270)

MRGSAHVVILGAGTGGMPAAYEMKEALGSGHEVTLISANDYFQFVPSNPW
VGVGWKERDDIAFPIRHYVERKGIHFIAQSAEQIDAEAQNITLADGNTVH
YDYLMIATGPKLAFENVPGSDPHEGPVQSICTVDHAERAFAEYQALLREP
GPIVIGAMAGASCFGPAYEYAMIVASDLKKRGMRDKIPSFTFITSEPYIG
HLGIQGVGDSKGILTKGLKEEGIEAYTNCKVTKVEDNKMYVTQVDEKGET
IKEMVLPVKFGMMIPAFKGVPAVAGVEGLCNPGGFVLVDEHQRSKKYANI
FAAGIAIAIPPVETTPVPTGAPKTGYMIESMVSAAVHNIKADLEGRKGEQ
TMGTWNAVCFADMGDRGAAFIALPQLKPRKVDVFAYGRWVHLAKVAFEKY
FIRKMKMGVSEPFYEKVLFKM

3D structure

• PDB: 3szc Structure-activity characterization of sulfide:quinone oxidoreductase variants.
• Chain: A
• Resolution: 2.2 Å

Enzymatic activity

• Catalytic site (original residue number in PDB): C128 C160 H198 C356 D359 K391
• Catalytic site (residue number reindexed from 1): C131 C163 H201 C359 D362 K394
• Enzyme Commision number: 1.8.5.4: bacterial sulfide:quinone reductase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	FAD	A	L7 G8 A9 G10 T11 G12 S34 A35 V42 P43 S77 A78 A104 T105 G106 P163 G301 I302 K320 T321 G322 V355 C356 F357	L10 G11 A12 G13 T14 G15 S37 A38 V45 P46 S80 A81 A107 T108 G109 P166 G304 I305 K323 T324 G325 V358 C359 F360
BS02	DCQ	A	P43 G322 Y323 V355 K391 F394 Y411 K413	P46 G325 Y326 V358 K394 F397 Y414 K416

Gene Ontology

Molecular Function

• GO:0000166 nucleotide binding
• GO:0016491 oxidoreductase activity
• GO:0048038 quinone binding
• GO:0070224 sulfide:quinone oxidoreductase activity

Cellular Component

• GO:0016020 membrane

External links

• PDB: RCSB:3szc, PDBe:3szc, PDBj:3szc
• PDBsum: 3szc
• PubMed: 22542586
• UniProt: B7JBP8|SQRD_ACIF2 Sulfide-quinone reductase (Gene Name=AFE_1792)