Structure of PDB 3sys Chain A

Receptor sequence

>3sysA (length=374) Species: 287 (Pseudomonas aeruginosa)

GFLEDAKTDLVLRNYYFNRDFLVDEWAQGFILKFSSGYTPGTVGVGLDAI
GLFGVKLNSNSELLPLHDDGRAADNYGRVGVAAKLRVSASELKIGEMLPD
IPLLRYDDGRLLPQTFRGFAVVSRELPGLALQAGRFDAVSLRNSADMQDL
SAWSAPTQKSDGFNYAGAEYRFNRERTQLGLWHGQLEDVYRQSYANLLHK
QRVGDWTLGANLGLFVDRDDGAARAGEIDSHTVYGLFSAGIGLHTFYLGL
QKVGGDSGWQSVYGSSGRSMGNDMFNGNFTNADERSWQVRYDYDFVGLGW
PGLIGMVRYGHGSNATTKAGSGGKEWERDVELGYTVQSGPLARLNVRLNH
ASNRRSFNSDFDQTRLVVSYPLSW

3D structure

• PDB: 3sys Substrate Specificity within a Family of Outer Membrane Carboxylate Channels.
• Chain: A
• Resolution: 1.65 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	C8E	A	H260 Y307	H244 Y291
BS02	C8E	A	Y307 G321 R344 V346	Y291 G305 R328 V330
BS03	C8E	A	L364 H366	L348 H350
BS04	C8E	A	L15 V384	L12 V368
BS05	C8E	A	L63 G93	L52 G77
BS06	C8E	A	Y181 R207	Y165 R191
BS07	C8E	A	L266 R301 S302 W303 H327 S329	L250 R285 S286 W287 H311 S313
BS08	VNL	A	K44 F45 D59 A60 I61 M113 L114	K33 F34 D48 A49 I50 M97 L98
BS09	VNL	A	H327 K340 W342 R370 R371 S372	H311 K324 W326 R354 R355 S356

Gene Ontology

Molecular Function

• GO:0015288 porin activity

Biological Process

• GO:0055085 transmembrane transport

Cellular Component

• GO:0016020 membrane

External links

• PDB: RCSB:3sys, PDBe:3sys, PDBj:3sys
• PDBsum: 3sys
• PubMed: 22272184
• UniProt: Q9HUR5