Structure of PDB 3sy8 Chain A

Receptor sequence
>3sy8A (length=389) Species: 208964 (Pseudomonas aeruginosa PAO1) [Search protein sequence]
MNDLNVLVLEDEPFQRLVAVTALKKVVPGSILEAADGKEAVAILESCGHV
DIAICDLQMSGMDGLAFLRHASLSGKVHSVILSSEVDPILRQATISMIEC
LGLNFLGDLGKPFSLERITALLTRYNARRQDLPRQAELPSVADVVRGLDN
GEFEAYYQPKVALDGGGLIGAEVLARWNHPHLGVLPPSHFLYVMETYNLV
DKLFWQLFSQGLATRRKLAQLGQPINLAFNVHPSQLGSRALAENISALLT
EFHLPPSSVMFEITETGLISAPASSLENLVRLWIMGCGLAMDDFGAGYSS
LDRLCEFPFSQIKLDRTFVQKMKTQPRSCAVISSVVALAQALGISLVVEG
VESDEQRVRLIELGCSIAQGYLFARPMPEQHFLDYCSGS
3D structure
PDB3sy8 Structural insights into the regulatory mechanism of the response regulator RocR from Pseudomonas aeruginosa in cyclic Di-GMP signaling.
ChainA
Resolution2.5 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.4.52: cyclic-guanylate-specific phosphodiesterase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG A E175 N233 E265 D295 E172 N230 E262 D292
Gene Ontology
Molecular Function
GO:0016787 hydrolase activity
GO:0046872 metal ion binding
GO:0071111 cyclic-guanylate-specific phosphodiesterase activity
Biological Process
GO:0000160 phosphorelay signal transduction system
GO:0045892 negative regulation of DNA-templated transcription

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Molecular Function
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Biological Process
External links
PDB RCSB:3sy8, PDBe:3sy8, PDBj:3sy8
PDBsum3sy8
PubMed22753070
UniProtQ9HX69|ROCR_PSEAE Cyclic di-GMP phosphodiesterase RocR (Gene Name=rocR)

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