Structure of PDB 3sxx Chain A

Receptor sequence

>3sxxA (length=666)

SAAPARPAHPLDPLSTAEIKAATNTVKSYFAGKKISFNTVTLREPARKAY
IQWKEQGGPLPPRLAYYVILEAGKPGVKEGLVDLASLSVIETRALETVQP
ILTVEDLCSTEEVIRNDPAVIEQCVLSGIPANEMHKVYCDPWTIGYDERW
GTGKRLQQALVYYRSDEDDSQYSHPLDFCPIVDTEEKKVIFIDIPNRRRK
VSKHKHANFYPKHMIEKVGAMRPEAPPINVTQPEGVSFKMTGNVMEWSNF
KFHIGFNYREGIVLSDVSYNDHGNVRPIFHRISLSEMIVPYGSPEFPHQR
KHALDIGEYGAGYMTNPLSLGCDCKGVIHYLDAHFSDRAGDPITVKNAVC
IHEEDDGLLFKHSDFRDNFATSLVTRATKLVVSQIFTAANYEYCLYWVFM
QDGAIRLDIRLTGILNTYILGDDEEAGPWGTRVYPNVNAHNHQHLFSLRI
DPRIDGDGNSAAACDAKSSPYPLGSPENMYGNAFYSEKTTFKTVKDSLTN
YESATGRSWDIFNPNKVNPYSGKPPSYKLVSTQCPPLLAKEGSLVAKRAP
WASHSVNVVPYKDNRLYPSGDHVPQWSGDGVRGMREWIGDGSENIDNTDI
LFFHTFGITHFPAPEDFPLMPAEPITLMLRPRHFFTENPGLDIQPSYAMT
TSEAKRAVAFEGSCCG

3D structure

• PDB: 3sxx The precursor form of Hansenula polymorpha copper amine oxidase 1 in complex with CuI and CoII.
• Chain: A
• Resolution: 1.27 Å

Enzymatic activity

• Catalytic site (original residue number in PDB): Y305 D319 Y405 H456 H458 H624
• Catalytic site (residue number reindexed from 1): Y291 D305 Y391 H442 H444 H610
• Enzyme Commision number: 1.4.3.21: primary-amine oxidase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	CO	A	Y405 H456 H458 H624	Y391 H442 H444 H610

Gene Ontology

Molecular Function

• GO:0005507 copper ion binding
• GO:0008131 primary methylamine oxidase activity
• GO:0016491 oxidoreductase activity
• GO:0046872 metal ion binding
• GO:0048038 quinone binding
• GO:0052595 aliphatic amine oxidase activity

Biological Process

• GO:0009308 amine metabolic process

Cellular Component

• GO:0005777 peroxisome

External links

• PDB: RCSB:3sxx, PDBe:3sxx, PDBj:3sxx
• PDBsum: 3sxx
• PubMed: 22691777
• UniProt: P12807|AMO_PICAN Peroxisomal primary amine oxidase (Gene Name=AMO)