Structure of PDB 3sx6 Chain A

Receptor sequence

>3sx6A (length=421) Species: 243159 (Acidithiobacillus ferrooxidans ATCC 23270)

MRGSAHVVILGAGTGGMPAAYEMKEALGSGHEVTLISANDYFQFVPSNPW
VGVGWKERDDIAFPIRHYVERKGIHFIAQSAEQIDAEAQNITLADGNTVH
YDYLMIATGPKLAFENVPGSDPHEGPVQSICTVDHAERAFAEYQALLREP
GPIVIGAMAGASCFGPAYEYAMIVASDLKKRGMRDKIPSFTFITSEPYIG
HLGIQGVGDSKGILTKGLKEEGIEAYTNCKVTKVEDNKMYVTQVDEKGET
IKEMVLPVKFGMMIPAFKGVPAVAGVEGLCNPGGFVLVDEHQRSKKYANI
FAAGIAIAIPPVETTPVPTGAPKTGYMIESMVSAAVHNIKADLEGRKGEQ
TMGTWNAVAFADMGDRGAAFIALPQLKPRKVDVFAYGRWVHLAKVAFEKY
FIRKMKMGVSEPFYEKVLFKM

3D structure

• PDB: 3sx6 Structure-activity characterization of sulfide:quinone oxidoreductase variants.
• Chain: A
• Resolution: 1.7955 Å

Enzymatic activity

• Catalytic site (original residue number in PDB): C128 C160 H198 A356 D359 K391
• Catalytic site (residue number reindexed from 1): C131 C163 H201 A359 D362 K394
• Enzyme Commision number: 1.8.5.4: bacterial sulfide:quinone reductase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	FAD	A	L7 G8 A9 G10 T11 G12 S34 A35 V42 P43 S77 A78 A104 T105 G106 C160 P163 G301 I302 T321 G322 I325 V355 F357	L10 G11 A12 G13 T14 G15 S37 A38 V45 P46 S80 A81 A107 T108 G109 C163 P166 G304 I305 T324 G325 I328 V358 F360
BS02	DCQ	A	G322 Y323 F357 I368 F394 F398 Y411	G325 Y326 F360 I371 F397 F401 Y414

Gene Ontology

Molecular Function

• GO:0000166 nucleotide binding
• GO:0016491 oxidoreductase activity
• GO:0048038 quinone binding
• GO:0070224 sulfide:quinone oxidoreductase activity

Cellular Component

• GO:0016020 membrane

External links

• PDB: RCSB:3sx6, PDBe:3sx6, PDBj:3sx6
• PDBsum: 3sx6
• PubMed: 22542586
• UniProt: B7JBP8|SQRD_ACIF2 Sulfide-quinone reductase (Gene Name=AFE_1792)