Structure of PDB 3su3 Chain A

Receptor sequence
>3su3A (length=201) [Search protein sequence]
GSHMASMKKKGSVVIVGRINLSGDTAYAQQTRGEEGCQETSQTGRDKNQV
EGEVQIVSTATQTFLATSINGVLWTVYHGAGTRTIASPKGPVTQMYTNVD
KDLVGWQAPQGSRSLTPCTCGSSDLYLVTRHADVIPVRRRGDSRGSLLSP
RPISYLKGSAGGPLLCPAGHAVGIFRAAVSTRGVAKAVDFIPVESLETTM
R
3D structure
PDB3su3 The Molecular Basis of Drug Resistance against Hepatitis C Virus NS3/4A Protease Inhibitors.
ChainA
Resolution1.3 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H1057 D1081 G1137 A1139
Catalytic site (residue number reindexed from 1) H78 D102 G158 A160
Enzyme Commision number 3.4.21.98: hepacivirin.
3.6.1.15: nucleoside-triphosphate phosphatase.
3.6.4.13: RNA helicase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SU3 A Q1041 F1043 H1057 D1081 L1135 K1136 G1137 A1139 F1154 R1155 A1156 A1157 Q62 F64 H78 D102 L156 K157 G158 A160 F175 R176 A177 A178 MOAD: Ki=0.74nM
PDBbind-CN: -logKd/Ki=9.13,Ki=0.74nM
BS02 ZN A C1097 C1099 C1145 H1149 C118 C120 C166 H170
Gene Ontology
Molecular Function
GO:0008236 serine-type peptidase activity
Biological Process
GO:0006508 proteolysis
GO:0019087 transformation of host cell by virus

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Molecular Function
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Biological Process
External links
PDB RCSB:3su3, PDBe:3su3, PDBj:3su3
PDBsum3su3
PubMed22910833
UniProtA8DG50

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