Structure of PDB 3std Chain A

Receptor sequence
>3stdA (length=162) Species: 148305 (Pyricularia grisea) [Search protein sequence]
GEITFSDYLGLMTCVYEWADSYDSKDWDRLRKVIAPTLRIDYRSFLDKLW
EAMPAEEFVGMVSSKQVLGDPTLRTQHFIGGTRWEKVSEDEVIGYHQLRV
PHQRYKDTTMKEVTMKGHAHSANLHWYKKIDGVWKFAGLKPDIRWGEFDF
DRIFEDGRETFG
3D structure
PDB3std Structure-based design of potent inhibitors of scytalone dehydratase: displacement of a water molecule from the active site.
ChainA
Resolution1.65 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) Y30 D31 Y50 H85 H110
Catalytic site (residue number reindexed from 1) Y22 D23 Y42 H77 H102
Enzyme Commision number 4.2.1.94: scytalone dehydratase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MQ0 A Y30 Y50 F53 V108 A127 N131 L147 P149 I151 G165 Y22 Y42 F45 V100 A119 N123 L139 P141 I143 G157 MOAD: Ki=7.7pM
PDBbind-CN: -logKd/Ki=11.11,Ki=7.7pM
Gene Ontology
Molecular Function
GO:0016829 lyase activity
GO:0030411 scytalone dehydratase activity
GO:0046872 metal ion binding
Biological Process
GO:0006582 melanin metabolic process
GO:0042438 melanin biosynthetic process
Cellular Component
GO:0005575 cellular_component
GO:0005768 endosome

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Cellular Component
External links
PDB RCSB:3std, PDBe:3std, PDBj:3std
PDBsum3std
PubMed9922139
UniProtP56221|SCYD_PYRO7 Scytalone dehydratase (Gene Name=SDH1)

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