Structure of PDB 3sqz Chain A

Receptor sequence
>3sqzA (length=388) Species: 1309 (Streptococcus mutans) [Search protein sequence]
MRIGIDKIGFTSSQYVLNMKDLAEARGEDPQKFSKGLLLNALSIAPITDD
VVTLAAGSANEILTAEDKEKIDMVILATESSVDQSKAGAVYVHSLLGIQP
FARSFEMKEACYSATAALNYAKLHVEKHPDTRVLVLASDIAKYGIGTPGE
STQGAGSIAMLVKKDPRILILHDETLAQTRDIMDFWRPNYTTTPYVNGMY
STKQYLDMLKTTWAEYQKRFDVSLTDFAAFCFHLPFPKLALKGFNKIMDK
QVPSDLQEKLKVNFEASILYSKQIGNIYTGSLFLGLLSLLENSQNLVAGD
KIALFSYGSGAVAEIFTGTLVKGFKEQLQTNRLDKLKRRTPLSVENYEKI
FFEEAQLDDKGNASFKEYQTGPFALKEILEHQRIYGKV
3D structure
PDB3sqz Crystal structure of HMG-CoA synthase from Streptococcus mutans
ChainA
Resolution1.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.3.10: hydroxymethylglutaryl-CoA synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 COA A D29 K32 G36 Y143 P148 G149 T152 F185 G198 S201 F236 K238 K242 D29 K32 G36 Y143 P148 G149 T152 F185 G198 S201 F236 K238 K242
Gene Ontology
Molecular Function
GO:0004421 hydroxymethylglutaryl-CoA synthase activity
GO:0016746 acyltransferase activity
Biological Process
GO:0006084 acetyl-CoA metabolic process
GO:0010142 farnesyl diphosphate biosynthetic process, mevalonate pathway

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Molecular Function
View graph for
Biological Process
External links
PDB RCSB:3sqz, PDBe:3sqz, PDBj:3sqz
PDBsum3sqz
PubMed
UniProtQ8DUI5

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