Structure of PDB 3spw Chain A

Receptor sequence
>3spwA (length=398) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence]
FLKSIASFNGDLSSLSAPPFILSPISLTEFSQYWAEHPELFLEPSFINDD
NYKEHCLIDPEVESPELARMLAVTKWFISTLKSQYCSEKKPLNPFLGELF
VGKWENKEHPEFGETVLLSEQVSHHPPVTAFSIFNDKNKVKLQGYNQIKA
SFMLTVKQFGHTMLDIKDESYLVTPPPLHIVELEGKSYIQSSTGLLCVIE
FSGRGKKNSFKARIYKDSKDSKDKEKALYTISGQWSGSSKIIKANKKEES
RLFYDAARIPAEHLNVKPLEEQHPLESRKAWYDVAGAIKLGDFNLIAKTK
TELEETQRELRKEEEAKGISWQRRWFKDFDYSVTPEEGALVPEKDDTFLK
LASALNLSTKNAPSGTLVGDKEDRKEDLSSIHWRFQRELWDEEKEIVL
3D structure
PDB3spw Osh4p exchanges sterols for phosphatidylinositol 4-phosphate between lipid bilayers.
ChainA
Resolution2.6 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 T7M A L24 S25 L27 S28 A29 Q96 K109 P110 N112 H143 H144 K336 E340 R344 L12 S13 L15 S16 A17 Q84 K90 P91 N93 H124 H125 K300 E304 R308
Gene Ontology
Molecular Function
GO:0005546 phosphatidylinositol-4,5-bisphosphate binding
GO:0008142 oxysterol binding
GO:0008289 lipid binding
GO:0070273 phosphatidylinositol-4-phosphate binding
GO:0070300 phosphatidic acid binding
GO:0120015 sterol transfer activity
Biological Process
GO:0006665 sphingolipid metabolic process
GO:0006869 lipid transport
GO:0006887 exocytosis
GO:0006892 post-Golgi vesicle-mediated transport
GO:0006897 endocytosis
GO:0015918 sterol transport
GO:0030011 maintenance of cell polarity
GO:0034727 piecemeal microautophagy of the nucleus
GO:0035621 ER to Golgi ceramide transport
Cellular Component
GO:0000139 Golgi membrane
GO:0005737 cytoplasm
GO:0005794 Golgi apparatus
GO:0005829 cytosol
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3spw, PDBe:3spw, PDBj:3spw
PDBsum3spw
PubMed22162133
UniProtP35844|KES1_YEAST Oxysterol-binding protein homolog 4 (Gene Name=KES1)

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