Structure of PDB 3sp7 Chain A

Receptor sequence
>3sp7A (length=150) Species: 9606 (Homo sapiens) [Search protein sequence]
SEFMSQSNRELVVDFLSYKLSQKGYSWSQFSDESEAVKQALREAGDEFEL
RYRRAFSDLTSQLHITPGTAYQSFEQVVNELFRDGVNWGRIVAFFSFGGA
LCVESVDKEMQVLVSRIAAWMATYLNDHLEPWIQENGGWDTFVELYGNNA
3D structure
PDB3sp7 Structure-based design of a new class of potent Bcl-2/Bcl-xL inhibitors
ChainA
Resolution1.4 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 03B A E96 F97 R100 Y101 A104 F105 E129 L130 N136 W137 G138 V141 A142 F146 Y195 N198 A199 E47 F48 R51 Y52 A55 F56 E80 L81 N87 W88 G89 V92 A93 F97 Y146 N149 A150 BindingDB: IC50=6.0nM
BS02 ZN A E7 D11 E10 D14
BS03 ZN A E124 H177 E75 H128
Gene Ontology
Biological Process
GO:0042981 regulation of apoptotic process

View graph for
Biological Process
External links
PDB RCSB:3sp7, PDBe:3sp7, PDBj:3sp7
PDBsum3sp7
PubMed
UniProtQ07817|B2CL1_HUMAN Bcl-2-like protein 1 (Gene Name=BCL2L1)

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