Structure of PDB 3sp6 Chain A

Receptor sequence
>3sp6A (length=270) Species: 9606 (Homo sapiens) [Search protein sequence]
EDSETADLKSLAKRIYEAYLKNFNMNKVKARVILSGKASNNPPFVIHDME
TLCMAEKTLVAKLVANNKEAEVRIFHCCQCTSVETVTELTEFAKAIPGFA
NLDLNDQVTLLKYGVYEAIFAMLSSVMNKDGMLVAYGNGFITREFLKSLR
KPFCDIMEPKFDFAMKFNALELDDSDISLFVAAIICCGDRPGLLNVGHIE
KMQEGIVHVLRLHLQSNHPDDIFLFPKLLQKMADLRQLVTEHAQLVQIIK
KTESDAALHPLLQEIYRDMY
3D structure
PDB3sp6 Structural basis for iloprost as a dual peroxisome proliferator-activated receptor alpha/delta agonist.
ChainA
Resolution2.21 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A K292 Q305 V306 L309 P458 L459 E462 K94 Q107 V108 L111 P260 L261 E264
BS02 IL2 A F273 C276 Q277 T279 S280 Y314 F318 I354 M355 H440 Y464 F75 C78 Q79 T81 S82 Y116 F120 I156 M157 H242 Y266
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003824 catalytic activity
GO:0004879 nuclear receptor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription
Cellular Component
GO:0005634 nucleus

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Molecular Function
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Cellular Component
External links
PDB RCSB:3sp6, PDBe:3sp6, PDBj:3sp6
PDBsum3sp6
PubMed21775429
UniProtQ07869|PPARA_HUMAN Peroxisome proliferator-activated receptor alpha (Gene Name=PPARA)

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