Structure of PDB 3soq Chain A

Receptor sequence
>3soqA (length=305) Species: 9606 (Homo sapiens) [Search protein sequence]
APLLLYANRRDLRLVDATNGKENATIVVGGLEDAAAVDFVFSHGLIYWSD
VSEEAIKRTEFNKTESVQNVVVSGLLSPDGLACDWLGEKLYWTDSETNRI
EVSNLDGSLRKVLFWQELDQPRAIALDPSSGFMYWTDWGEVPKIERAGMD
GSSRFIIINSEIYWPNGLTLDYEEQKLYWADAKLNFIHKSNLDGTNRQAV
VKGSLPHPFALTLFEDILYWTDWSTHSILACNKYTGEGLREIHSDIFSPM
DIHAFSQQRQPNATNPCGIDNGGCSHLCLMSPVKPFYQCACPTGVKLLEN
GKTCK
3D structure
PDB3soq Wnt antagonists bind through a short peptide to the first beta-propeller domain of LRP5/6.
ChainA
Resolution1.9 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A R28 V70 L95 D98 E115 R141 W157 W183 N185 H226 W242 R9 V51 L76 D79 E96 R122 W138 W164 N166 H207 W223
BS02 CA A S114 N117 D138 S95 N98 D119
External links
PDB RCSB:3soq, PDBe:3soq, PDBj:3soq
PDBsum3soq
PubMed21944579
UniProtO75581|LRP6_HUMAN Low-density lipoprotein receptor-related protein 6 (Gene Name=LRP6)

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