Structure of PDB 3soc Chain A

Receptor sequence
>3socA (length=307) Species: 9606 (Homo sapiens) [Search protein sequence]
LGTENLYFQSMPLQLLEVKARGRFGCVWKAQLLNEYVAVKIFPIQDKQSW
QNEYEVYSLPGMKHENILQFIGAEKRGTSVDVDLWLITAFHEKGSLSDFL
KANVVSWNELCHIAETMARGLAYLHEDIPGLKDGHKPAISHRDIKSKNVL
LKNNLTACIADFGLALKFEAGKSAGDTHGQVGTRRYMAPEVLEGAINFQR
DAFLRIDMYAMGLVLWELASRCTAADGPVDEYMLPFEEEIGQHPSLEDMQ
EVVVHKKKRPVLRDYWQKHAGMAMLCETIEECWDHDAEARLSAGCVGERI
TQMQRLT
3D structure
PDB3soc Crystal structure of Activin receptor type-IIA (ACVR2A) kinase domain in complex with a quinazolin
ChainA
Resolution1.95 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D322 K324 N327 D340 T362
Catalytic site (residue number reindexed from 1) D143 K145 N148 D161 T183
Enzyme Commision number 2.7.11.30: receptor protein serine/threonine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GVD A K198 V206 A217 L247 F269 H270 E271 G273 K326 L329 D340 K19 V27 A38 L68 F90 H91 E92 G94 K147 L150 D161
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004675 transmembrane receptor protein serine/threonine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation
GO:0007178 cell surface receptor protein serine/threonine kinase signaling pathway
Cellular Component
GO:0016020 membrane

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Cellular Component
External links
PDB RCSB:3soc, PDBe:3soc, PDBj:3soc
PDBsum3soc
PubMed
UniProtP27037|AVR2A_HUMAN Activin receptor type-2A (Gene Name=ACVR2A)

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