Structure of PDB 3snp Chain A

Receptor sequence

>3snpA (length=850) Species: 9986 (Oryctolagus cuniculus)

SNPFAYLAEPLDPAQPGKKFFNLNKLDYSRYGRLPFSIRVLLEAAVRNCD
KFLVKKEDIENILNWNVTQHMNIEVPFKPARVILQDFTGVPSVVDFAAMR
DAVKKLGGDPEKINPICPVDLVIDHSEFERNRERFEFLKWGSKAFRNMRI
IPPGSGIIHQVNLEYLARVVFDQDGYYYPDSLVGTDSHTTMIDGLGVLGW
GVGGIEAEAVMLGQPISMVLPQVIGYRLMGKPHPLVTSTDIVLTITKHLR
QVGVVGKFVEFFGPGVAQLSIADRATIANMCPEYGATATFFPVDEVSIKY
LVQTGRDESKVKQIRKYLQAVGMFRDYSDPSQDPDFTQVVELDLKTVVPC
CSGPKRPQDKVAVSDMKKDFESCLGAKQGFKGFQVAPDHHNDHKTFIYND
SEFTLSHGSVVIAAITSSTNTSNPSVMLGAGLLAKKAVDAGLNVKPYVKT
SLSPGSGVVTYYLRESGVMPYLSQLGFDVVPLPEPVVEAITQGDLVAVGV
LSGNRNFEGRVHPNTRANYLASPPLVIAYAIAGTIRIDFEKEPLGTNAKG
QQVFLRDIWPTREEIQAVERQYVIPGMFTEVYQKIETVNASWKLYLWNPK
STYIKSPPFFENLTLDLQPPKSIVDAYVLLNLGDSVTTDHISPAGNIARN
SPAARYLTNRGLTPREFNSYGSRRGNDAIMARGTFANIRLLNRFLNKQAP
QTIHLPSGETLDVFDAAERYQQEGHPLIVLAGKEYGSGSSRDWAAKGPFL
LGIKAVLAESYERIHRSNLVGMGVIPLEYLPGENADSLGLTGRERYTIII
PENLTPRMHVQVKLDTGKTFQAVIRFDTDVELTYFHNGGILNYMIRKMAK

3D structure

• PDB: 3snp Structure of dual function iron regulatory protein 1 complexed with ferritin IRE-RNA.
• Chain: A
• Resolution: 2.8 Å

Enzymatic activity

• Catalytic site (original residue number in PDB): D125 H126 D205 R536 S778 R780
• Catalytic site (residue number reindexed from 1): D124 H125 D186 R505 S739 R741
• Enzyme Commision number: 4.2.1.3: aconitate hydratase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	A	H126 S127 H207 L262 R269 N298 E302 S371 P376 K379 T438 N439 T440 N535 R536 L551 S681 P682 A683 G684 N685 R688 R704 S708 G710 R713 R780	H125 S126 H188 L243 R250 N279 E283 S352 P357 K360 T419 N420 T421 N504 R505 L520 S642 P643 A644 G645 N646 R649 R665 S669 G671 R674 R741

Gene Ontology

Molecular Function

• GO:0003723 RNA binding
• GO:0003994 aconitate hydratase activity
• GO:0016829 lyase activity
• GO:0030350 iron-responsive element binding
• GO:0046872 metal ion binding
• GO:0051538 3 iron, 4 sulfur cluster binding
• GO:0051539 4 iron, 4 sulfur cluster binding

Biological Process

• GO:0006099 tricarboxylic acid cycle
• GO:0006101 citrate metabolic process
• GO:0010040 response to iron(II) ion

Cellular Component

• GO:0005737 cytoplasm
• GO:0005739 mitochondrion
• GO:0005829 cytosol

External links

• PDB: RCSB:3snp, PDBe:3snp, PDBj:3snp
• PDBsum: 3snp
• PubMed: 17185597
• UniProt: Q01059|ACOHC_RABIT Cytoplasmic aconitate hydratase (Gene Name=ACO1)