Structure of PDB 3smi Chain A

Receptor sequence
>3smiA (length=177) Species: 9606 (Homo sapiens) [Search protein sequence]
QNFCVVELLPSDPEYNTVASKFNQTCSHFRIEKIERIQNPDLWNSYQAKK
KTMDAKNGQTMNEKQLFHGTDAGSVPHVNRNGFNRSYAAYGKGTYFAVNA
NYSANDTYSRPDANGRKHVYYVRVLTGIYTHGNHSLIVPPSKNDLYDTVT
DNVHHPSLFVAFYDYQAYPEYLITFRK
3D structure
PDB3smi Family-wide chemical profiling and structural analysis of PARP and tankyrase inhibitors.
ChainA
Resolution2.4 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.4.2.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 QDR A H1601 G1602 Y1620 Y1633 S1641 Y1646 H68 G69 Y87 Y95 S103 Y108
Gene Ontology
Molecular Function
GO:0003950 NAD+-protein poly-ADP-ribosyltransferase activity

View graph for
Molecular Function
External links
PDB RCSB:3smi, PDBe:3smi, PDBj:3smi
PDBsum3smi
PubMed22343925
UniProtQ460N5|PAR14_HUMAN Protein mono-ADP-ribosyltransferase PARP14 (Gene Name=PARP14)

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