Structure of PDB 3sm8 Chain A

Receptor sequence

>3sm8A (length=381) Species: 287 (Pseudomonas aeruginosa)

HHHHHHPIEADYLVIGAGIAGASTGYWLSAHGRVVVLEREAQPGYHSTGR
SAAHYTVAYGTPQVRALTAASRAFFDNPPAGFCEHPLLSPRPEMVVDFSD
DPEELRRQYESGKALVPQMRLLDAEQACSIVPVLRRDKVFGATYDPTGAD
IDTDALHQGYLRGIRRNQGQVLCNHEALEIRRVDGAWEVRCDAGSYRAAV
LVNAAGAWCDAIAGLAGVRPLGLQPKRRSAFIFAPPPGIDCHDWPMLVSL
DESFYLKPDAGMLLGSPANADPVEAHDVQPEQLDIATGMYLIEEATTLTI
RRPEHTWAGLRSFVADGDLVAGYAANAEGFFWVAAQGGYGIQTSAAMGEA
SAALIRHQPLPAHLREHGLDEAMLSPRRLSP

3D structure

• PDB: 3sm8 Atomic-resolution structure of an N5 flavin adduct in D-arginine dehydrogenase.
• Chain: A
• Resolution: 1.07 Å

Enzymatic activity

• Enzyme Commision number: 1.4.99.6: D-arginine dehydrogenase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	FNK	A	I1009 G1010 G1012 I1013 A1014 L1031 E1032 R1033 H1040 S1041 T1042 R1044 S1045 A1046 H1048 Y1053 E1170 A1171 A1199 G1200 W1202 I1206 R1222 M1240 Y1249 G1303 R1305 Q1330 G1331 G1332 Y1333 G1334 I1335 Q1336	I15 G16 G18 I19 A20 L37 E38 R39 H46 S47 T48 R50 S51 A52 H54 Y59 E176 A177 A205 G206 W208 I212 R228 M246 Y255 G309 R311 Q336 G337 G338 Y339 G340 I341 Q342

Gene Ontology

Molecular Function

• GO:0000166 nucleotide binding
• GO:0008718 D-amino-acid dehydrogenase activity
• GO:0016491 oxidoreductase activity

Biological Process

• GO:0006525 arginine metabolic process
• GO:0006527 arginine catabolic process

Cellular Component

• GO:0005737 cytoplasm

External links

• PDB: RCSB:3sm8, PDBe:3sm8, PDBj:3sm8
• PDBsum: 3sm8
• PubMed: 21707047
• UniProt: Q9HXE3|DAUA_PSEAE FAD-dependent catabolic D-arginine dehydrogenase DauA (Gene Name=dauA)