Structure of PDB 3sjo Chain A

Receptor sequence
>3sjoA (length=179) Species: 39054 (Enterovirus A71) [Search protein sequence]
LDFALSLLRRNIRQVQTDQGHFTMLGVRDRLAVLPRHSQPGKTIWIEHKL
VNVLDAVELVDEQGVNLELTLITLDTNEKFRDITKFIPENISTASDATLV
INTEHMPSMFVPVGDVVQYGFLNLSGKPTHRTMMYNFPTKAGQCGGVVTS
VGKVIGIHIGGNGRQGFCAGLKRSYFASE
3D structure
PDB3sjo Enterovirus 71 and Coxsackievirus A16 3C Proteases: Binding to Rupintrivir and Their Substrates and Anti-Hand, Foot, and Mouth Disease Virus Drug Design.
ChainA
Resolution1.702 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H40 E71 G145 C147
Catalytic site (residue number reindexed from 1) H37 E68 G142 C144
Enzyme Commision number 2.7.7.48: RNA-directed RNA polymerase.
3.4.22.28: picornain 3C.
3.4.22.29: picornain 2A.
3.6.1.15: nucleoside-triphosphate phosphatase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 AG7 A R39 H40 E71 L127 S128 K130 T142 A144 C147 H161 G163 G164 N165 F170 R36 H37 E68 L124 S125 K127 T139 A141 C144 H158 G160 G161 N162 F167 PDBbind-CN: -logKd/Ki=5.78,IC50=1.65uM
Gene Ontology
Molecular Function
GO:0004197 cysteine-type endopeptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:3sjo, PDBe:3sjo, PDBj:3sjo
PDBsum3sjo
PubMed21795339
UniProtE0WWC7

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