Structure of PDB 3sji Chain A

Receptor sequence
>3sjiA (length=179) Species: 31704 (Coxsackievirus A16) [Search protein sequence]
LDFALSLLRRNIRQVQTDQGHFTMLGVRDRLAILPRHSQPGKTIWVEHKL
INVLDAVELVDEQGVNLELTLVTLDTNEKFRDVTKFIPETITGASDATLI
INTEHMPSMFVPVGDVVQYGFLNLSGKPTHRTMMYNFPTKAGQCGGVVTS
VGKIIGIHIGGNGRQGFCAGLKRGYFASE
3D structure
PDB3sji Enterovirus 71 and Coxsackievirus A16 3C Proteases: Binding to Rupintrivir and Their Substrates and Anti-Hand, Foot, and Mouth Disease Virus Drug Design.
ChainA
Resolution1.798 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H40 E71 G145 C147
Catalytic site (residue number reindexed from 1) H37 E68 G142 C144
Enzyme Commision number 3.4.22.28: picornain 3C.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 AG7 A H40 E71 L125 L127 S128 K130 T142 K143 A144 C147 H161 I162 G163 G164 N165 H37 E68 L122 L124 S125 K127 T139 K140 A141 C144 H158 I159 G160 G161 N162 PDBbind-CN: -logKd/Ki=5.69,IC50=2.06uM
Gene Ontology
Molecular Function
GO:0004197 cysteine-type endopeptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:3sji, PDBe:3sji, PDBj:3sji
PDBsum3sji
PubMed21795339
UniProtC8CIL7

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