Structure of PDB 3si7 Chain A

Receptor sequence
>3si7A (length=265) Species: 10090 (Mus musculus) [Search protein sequence]
TGIIMENVTAFWEEGFGELLEKVQSFSHLCLVGNPVLKNINLNIEKGEML
AITGSTGSGKTSLLMLILGELEASEGIIKHSGRVSFCSQFSWIMPGTIKE
NIIGVSYDEYRYKSVVKACQLQQDITKFAEQDNTVLGEGGVTLSGGQRAR
ISLARAVYKDADLYLLDSPFGYLDVFTEEQVFESCVCKLMANKTRILVTS
KMEHLRKADKILILHQGSSYFYGTFSELQSLRPDFSSKLMGYDTFDQFTE
ERRSSILTETLRRFS
3D structure
PDB3si7 Requirements for efficient correction of DeltaF508 CFTR revealed by analyses of evolved sequences
ChainA
Resolution2.25 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 5.6.1.6: channel-conductance-controlling ATPase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ATP A W401 Q413 F430 T460 G461 S462 G463 K464 T465 S466 W12 Q24 F26 T56 G57 S58 G59 K60 T61 S62
BS02 MG A Q413 T465 Q24 T61
BS03 MG A G451 A596 G47 A191
Gene Ontology
Molecular Function
GO:0005524 ATP binding
GO:0016887 ATP hydrolysis activity

View graph for
Molecular Function
External links
PDB RCSB:3si7, PDBe:3si7, PDBj:3si7
PDBsum3si7
PubMed22265409
UniProtP26361|CFTR_MOUSE Cystic fibrosis transmembrane conductance regulator (Gene Name=Cftr)

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