Structure of PDB 3sgu Chain A

Receptor sequence
>3sguA (length=213) Species: 187420 (Methanothermobacter thermautotrophicus str. Delta H) [Search protein sequence]
NRLILAMDLMNRDDALRVTGEVREYIDTVKIGYPLVLSEGMDIIAEFRKR
FGCRIIADFKVADIPETNEKICRATFKAGADAIIVHGFPGADSVRACLNV
AEEMGREVFLLTEMSHPGAEMFIQGAADEIARMGVDLGVKNYVGPSTRPE
RLSRLREIIGQDSFLISPGVGAQGGDPGETLRFADAIIVGRSIYLADNPA
AAAAGIIESIKDL
3D structure
PDB3sgu Crystal structure of Methanothermobacter thermautotrophicus orotidine 5'-monophosphate decarboxylase covalently modified by 5-fluoro-6-iodo-UMP
ChainA
Resolution1.7 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) K42 D70 K72 D75
Catalytic site (residue number reindexed from 1) K30 D58 K60 D63
Enzyme Commision number 4.1.1.23: orotidine-5'-phosphate decarboxylase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 5FU A D20 K72 L123 M126 S127 P180 Q185 G202 R203 D8 K60 L111 M114 S115 P168 Q173 G190 R191 BindingDB: Ki=645000nM
Gene Ontology
Molecular Function
GO:0004590 orotidine-5'-phosphate decarboxylase activity
GO:0016831 carboxy-lyase activity
Biological Process
GO:0006207 'de novo' pyrimidine nucleobase biosynthetic process
GO:0006221 pyrimidine nucleotide biosynthetic process
GO:0044205 'de novo' UMP biosynthetic process
Cellular Component
GO:0005829 cytosol

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Cellular Component
External links
PDB RCSB:3sgu, PDBe:3sgu, PDBj:3sgu
PDBsum3sgu
PubMed
UniProtO26232|PYRF_METTH Orotidine 5'-phosphate decarboxylase (Gene Name=pyrF)

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