Structure of PDB 3sfg Chain A

Receptor sequence
>3sfgA (length=480) Species: 223997 (Murine norovirus 1) [Search protein sequence]
LPRPSGTYAGLPIADYGDAPPLSTKTMFWRTSPEKLPPGAWEPAYLGSKD
ERVDGPSLQQVMRDQLKPYSEPRGLLPPQEILDAVCDAIENRLENTLEPQ
KPWTFKKACESLDKNTSSGYPYHKQKSKDWTGSAFIGDLGDQATHANNMY
EMGKSMRPIYTAALKDELVKPDKIYGKIKKRLLWGSDLGTMIRAARAFGP
FCDALKETCIFNPIRVGMSMNEDGPFIFARHANFRYHMDADYTRWDSTQQ
RAILKRAGDIMVRLSPEPDLARVVMDDLLAPSLLDVGDYKIVVEEGLPSG
CPCTTQLNSLAHWILTLCAMVEVTRVDPDIVMQESEFSFYGDDEVVSTNL
ELDMVKYTMALRRYGLLPTRADKEEGPLERRQTLQGISFLRRAIVGDQFG
WYGRLDRASIDRQLLWTKGPNHQNPFETLPGHAQRPSQLMALLGEAAMHG
EKYYRTVASRVSKMVVPRHRSVLRWVRFGT
3D structure
PDB3sfg Crystal structures of murine norovirus-1 RNA-dependent RNA polymerase in complex with 2-thiouridine or ribavirin.
ChainA
Resolution2.209 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.48: RNA-directed RNA polymerase.
3.4.22.66: calicivirin.
3.6.1.15: nucleoside-triphosphate phosphatase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 2TU A D250 S303 N312 Y344 D346 D246 S299 N308 Y340 D342 MOAD: Kd=0.865uM
PDBbind-CN: -logKd/Ki=6.06,Kd=0.865uM
BS02 MG A D243 D347 E348 S392 D239 D343 E344 S388
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003968 RNA-dependent RNA polymerase activity
GO:0004386 helicase activity
GO:0005524 ATP binding
Biological Process
GO:0006351 DNA-templated transcription
GO:0039694 viral RNA genome replication

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Molecular Function
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Biological Process
External links
PDB RCSB:3sfg, PDBe:3sfg, PDBj:3sfg
PDBsum3sfg
PubMed22341781
UniProtQ80J95|POLG_MNV1 Genome polyprotein (Gene Name=ORF1)

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