Structure of PDB 3seq Chain A

Receptor sequence
>3seqA (length=661) Species: 1773 (Mycobacterium tuberculosis) [Search protein sequence]
SMNFYSAYQHGFVRVAACTHHTTIGDPAANAASVLDMARACHDDGAALAV
FPELTLSGYSIEDVLLQDSLLDAVEDALLDLVTESADLLPVLVVGAPLRH
RHRIYNTAVVIHRGAVLGVVPKSYLPTYREFYERRQMAPGDGERGTIRIG
GADVAFGTDLLFAASDLPGFVLHVEIAEDMFVPMPPSAEAALAGATVLAN
LSGSPITIGRAEDRRLLARSASARCLAAYVYAAAGEGESTTDLAWDGQTM
IWENGALLAESERFPKGVRRSVADVDTELLRSERLRMGTFDDNRRHHREL
TESFRRIDFALDPPAGDIGLLREVERFPFVPADPQRLQQDCYEAYNIQVS
GLEQRLRALDYPKVVIGVSGGLDSTHALIVATHAMDREGRPRSDILAFAL
PGFKNNAIKLARALGVTFSEIDIGDTARLMLHTIGHPYSVGEKVYDVTFE
NVQAGLRTDYLFRIANQRGGIVLGTGDLSELALGWSTYGVGDQMSHYNVN
AGVPKTLIQHLIRWVISAGEFGEKVGEVLQSVLDTEITSEAKVGPFALQD
FSLFQVLRYGFRPSKIAFLAWHAWNDAERGNWPPGFPKSERPSYSLAEIR
HWLQIFVQRFYSFSQFKRSALPNGPKVSHGGALSPRGDWRAPSDMSARIW
LDQIDREVPKG
3D structure
PDB3seq Regulation of the intersubunit ammonia tunnel in Mycobacterium tuberculosis glutamine-dependent NAD+ synthetase.
ChainA
Resolution2.7342 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 6.3.5.1: NAD(+) synthase (glutamine-hydrolyzing).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 APC A G366 V367 S368 G370 L371 D372 S373 L399 R462 T480 G367 V368 S369 G371 L372 D373 S374 L400 R457 T475
BS02 DND A V452 E485 W490 T492 Y493 D497 F634 K635 V447 E480 W485 T487 Y488 D492 F616 K617
BS03 DND A R354 L358 N471 G475 H501 R355 L359 N466 G470 H496
Gene Ontology
Molecular Function
GO:0003952 NAD+ synthase (glutamine-hydrolyzing) activity
GO:0004359 glutaminase activity
GO:0005524 ATP binding
GO:0008795 NAD+ synthase activity
GO:0016874 ligase activity
GO:0042802 identical protein binding
Biological Process
GO:0009435 NAD biosynthetic process
Cellular Component
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0009274 peptidoglycan-based cell wall

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3seq, PDBe:3seq, PDBj:3seq
PDBsum3seq
PubMed22280445
UniProtP9WJJ3|NADE_MYCTU Glutamine-dependent NAD(+) synthetase (Gene Name=nadE)

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