Structure of PDB 3sd5 Chain A

Receptor sequence
>3sd5A (length=817) Species: 9606 (Homo sapiens) [Search protein sequence]
SEESQAFQRQLTALIGYDVTDVSNVHDDELEFTRRGLVTPRMAEVASRDP
KLYAMHPWVTSKPLPEYLWKNCIFIVIHRSTTSQTIKVSPDDTPGAILQS
FFTKMQDFVLRVCGRDEYLVGETPIKNFQWVRHCLKNGEEIHVVLDTPPD
PALDEVRKCDRKFRVKIRGIDIPVLTVFVEANIQHGQQVLCQRRTSPKPF
TEEVLWNVWLEFSIKIKDLPKGALLNLQIYCVRLLYYVNLLLIDHRFLLR
RGEYVLHMWQISGNADKLTSATNPDKENSMSISILLDNMPNQLRKQLEAI
IATDPLNPLTAEDKELLWHFRYESLKHPKAYPKLFSSVKWGQQEIVAKTY
QLLARREVWDQSALDVGLTMQLLDCNFSDENVRAIAVQKLESLEDDDVLH
YLLQLVQAVKFEPYHDSALARFLLKRGLRNKRIGHFLFWFLRSEIAQSRH
YQQRFAVILEAYLRGCGTAMLHDFTQQVQVIEMLQKVTLDIKSLSAEKYD
VSSQVISQLKQKLENLQNSQLPESFRVPYDPGLKAGALAIEKCKVMASKK
KPLWLEFKCADPTANETIGIIFKHGDDLRQDMLILQILRIMESIWETESL
DLCLLPYGCISTGDKIGMIEIVKDATTIAKIQQSTVTGAFKDEVLNHWLK
EKSPTEEKFQAAVERFVYSCAGYCVATFVLGIGDRHNDNIMITETGNLFH
IDFGHILGNRVPFVLTPDFLFVMGTSKTSPHFQKFQDICVKAYLALRHHT
NLLIILFSMMLMTGMQLTSKEDIEYIRDALTVGKNEEDAKKYFLDQIEVC
RDKGWTVQFNWFLHLVL
3D structure
PDB3sd5 Identification and Characterization of NVP-BKM120, an Orally Available Pan-Class I PI3-Kinase Inhibitor.
ChainA
Resolution3.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
2.7.1.137: phosphatidylinositol 3-kinase.
2.7.1.153: phosphatidylinositol-4,5-bisphosphate 3-kinase.
2.7.1.154: phosphatidylinositol-4-phosphate 3-kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SD5 A M804 P810 I831 I879 E880 V882 T887 D964 M546 P552 I571 I619 E620 V622 T627 D702 PDBbind-CN: -logKd/Ki=6.58,IC50=262nM
BindingDB: Kd=130nM,IC50=262nM
Gene Ontology
Molecular Function
GO:0016301 kinase activity
Biological Process
GO:0046854 phosphatidylinositol phosphate biosynthetic process

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:3sd5, PDBe:3sd5, PDBj:3sd5
PDBsum3sd5
PubMed22188813
UniProtP48736|PK3CG_HUMAN Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (Gene Name=PIK3CG)

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