Structure of PDB 3scl Chain A

Receptor sequence

>3sclA (length=597) Species: 9606,9675

STTEELAKTFLETFNYEAQELSYQSSVASWNYNTNITEENVQNMNNAGDK
WSAFLKEQSTLAQTYPLQEIQNLTVKLQLQALQQNGSSVLSEDKSKRLNT
ILNTMSTIYSTGKVCNPDNPQECLLLEPGLNEIMANSLDYNERLWAWESW
RSEVGKQLRPLYEEYVVLKNEMARANHYEDYGDYWRGDYEVNGVDGYDYS
RGQLIEDVEHTFEEIKPLYEHLHAYVRAKLMNAYPSYISPIGCLPAHLLG
DMWGRFWTNLYSLTVPFGQKPNIDVTDAMVDQAWDAQRIFKEAEKFFVSV
GLPNMTQGFWENSMLTDPGNVQKAVCHPTAWDLGKGDFRILMCTKVTMDD
FLTAHHEMGHIQYDMAYAAQPFLLRNGANEGFHEAVGEIMSLSAATPKHL
KSIGLLSPDFQEDNETEINFLLKQALTIVGTLPFTYMLEKWRWMVFKGEI
PKDQWMKKWWEMKREIVGVVEPVPHDETYCDPASLFHVSNDYSFIRYYTR
TLYQFQFQEALCQAAKHEGPLHKCDISNSTEAGQKLFNMLRLGKSEPWTL
ALENVVGAKNMNVRPLLNYFEPLFTWLKDQNKNSFVGWSTDWSPYAD

3D structure

• PDB: 3scl Mechanisms of host receptor adaptation by severe acute respiratory syndrome coronavirus.
• Chain: A
• Resolution: 3.0 Å

Enzymatic activity

• Catalytic site (original residue number in PDB): H345 P346 H374 E375 H378 E402 H505 Y515
• Catalytic site (residue number reindexed from 1): H327 P328 H356 E357 H360 E384 H487 Y497
• Enzyme Commision number: 3.4.17.-
  3.4.17.23: angiotensin-converting enzyme 2.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	ZN	A	H374 H378 E402	H356 H360 E384

Gene Ontology

Molecular Function

• GO:0008237 metallopeptidase activity
• GO:0008241 peptidyl-dipeptidase activity

Biological Process

• GO:0006508 proteolysis

Cellular Component

• GO:0016020 membrane

External links

• PDB: RCSB:3scl, PDBe:3scl, PDBj:3scl
• PDBsum: 3scl
• PubMed: 22291007
• UniProt: Q56NL1|ACE2_PAGLA Angiotensin-converting enzyme 2 (Gene Name=ACE2);
  Q9BYF1|ACE2_HUMAN Angiotensin-converting enzyme 2 (Gene Name=ACE2)