Structure of PDB 3sc0 Chain A

Receptor sequence
>3sc0A (length=237) Species: 9606 (Homo sapiens) [Search protein sequence]
EPKVAELKQKIEDTLCPFGFEVYPFQVAWYNELLPPAFHLPLPGPTLAFL
VLSTPAMFDRALKPFLQSCHLRMLTDPVDQCVAYHLGRVRESLPELQIEI
IADYEVHPNRRPKILAQTAAHVAGAAYYYQRQDVEADPWGNQRISGVCIH
PRFGGWFAIRGVVLLPGIEVPDLPPRKPHDCVPTRADRIALLEGFNFHWR
DWTYRDAVTPQERYSEEQKAYFSTPPAQRLALLGLAQ
3D structure
PDB3sc0 Structural basis of multifunctionality in a vitamin B12-processing enzyme.
ChainA
Resolution1.95 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.16.1.6: cyanocobalamin reductase.
2.5.1.151: alkylcobalamin dealkylase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 COB A L34 L35 P36 D104 P113 I115 A117 Q118 H122 Y129 Q131 S146 C149 I160 F196 W200 L33 L34 P35 D103 P112 I114 A116 Q117 H121 Y128 Q130 S145 C148 I159 F195 W199
External links
PDB RCSB:3sc0, PDBe:3sc0, PDBj:3sc0
PDBsum3sc0
PubMed21697092
UniProtQ9Y4U1|MMAC_HUMAN Cyanocobalamin reductase / alkylcobalamin dealkylase (Gene Name=MMACHC)

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